WRNIP1
Werner helicase interacting protein 1
Synonyms:
RP11-420G6.2, WHIP, bA420G6.2
Species:
Human WRNIP1 (56897), Mouse Wrnip1 (78903), Rat Wrnip1 (282835), sheep WRNIP1 (101123507), cow WRNIP1 (788824), domestic cat WRNIP1 (101087922), dog WRNIP1 (478698), chicken WRNIP1 (395089), Zebrafish wrnip1 (405856), domestic guinea pig Wrnip1 (100720377) ...More
UniProtKB ID:
Gene ID:
- Human(56897) Summary: Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
- Mouse(78903) Werner helicase interacting protein 1
- Rat(282835) Werner helicase interacting protein 1
- sheep(101123507) Werner helicase interacting protein 1
- cow(788824) Werner helicase interacting protein 1
- domestic cat(101087922) Werner helicase interacting protein 1
- dog(478698) Werner helicase interacting protein 1
- chicken(395089) Werner helicase interacting protein 1
- Zebrafish(405856) Werner helicase interacting protein 1
- domestic guinea pig(100720377) Werner helicase interacting protein 1
- naked mole-rat(101701117) Werner helicase interacting protein 1
- cow(782711) WRNIP1 protein-like
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