WRAP53
WD repeat containing, antisense to TP53
Synonyms:
DKCB3, TCAB1, WDR79
Species:
Human WRAP53 (55135), Mouse Wrap53 (216853), Rat Wrap53 (287432), Domestic Rabbit WRAP53 (100343593), domestic guinea pig Wrap53 (100733673), dog WRAP53 (607892), naked mole-rat Wrap53 (101702587), domestic cat WRAP53 (101099509), cow WRAP53 (509631), sheep WRAP53 (101103738)
UniProtKB ID:
Gene ID:
- Human(55135) Summary: This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
- Mouse(216853) WD repeat containing, antisense to Trp53
- Rat(287432) WD repeat containing, antisense to TP53
- Domestic Rabbit(100343593) WD repeat containing, antisense to TP53
- domestic guinea pig(100733673) WD repeat containing, antisense to TP53
- dog(607892) WD repeat containing, antisense to TP53
- naked mole-rat(101702587) WD repeat containing, antisense to TP53
- domestic cat(101099509) WD repeat containing, antisense to TP53
- cow(509631) WD repeat containing, antisense to TP53
- sheep(101103738) WD repeat containing, antisense to TP53
- Zebrafish(321796) WD repeat containing, antisense to TP53
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