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Merck

VHL

von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

Synonyms:
HRCA1, RCA1, VHL1, pVHL
Species:
Human VHL (7428), Mouse Vhl (22346), Rat Vhl (24874), domestic guinea pig Vhl (100729230), sheep VHL (101122897), cow VHL (540957), domestic cat VHL (101092590), dog VHL (494000), chicken VHL (416117), Zebrafish vhl (791202)
UniProtKB ID:
P40337, B2RE45, Q13599, Q6PDA9
Gene ID:
  • Human(7428) Summary: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  • Mouse(22346) von Hippel-Lindau tumor suppressor
  • Rat(24874) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • domestic guinea pig(100729230) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • sheep(101122897) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • cow(540957) von Hippel-Lindau tumor suppressor
  • domestic cat(101092590) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • dog(494000) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • chicken(416117) von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
  • Zebrafish(791202) von Hippel-Lindau tumor suppressor
  • fruit fly(53433) von Hippel-Lindau

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
HPA068954
Anti-Vhl Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
MABC14
Anti-VHL Antibody, clone 11E12, clone 11E12, from mouse,
Species Reactivity
human, mouse
Application
immunoprecipitation (IP)
western blot
ZRB2230
Anti-VHL Antibody, clone 1C10 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, rat
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot

Proteins

Product Number
Description
Species
SRP2084
VHL human, recombinant, expressed in insect cells, ≥70% (SDS-PAGE),
Species
human
23-044-M
VHL Protein Complex, Active, 10 µg, Active complex of five (5) recombinant human enzymes: VHL amino acids 54-end, full length Elongin C, full length Elongin B, full length Cul2, & full length Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.,
Species
human

esiRNA

Product Number
Description
Species
EHU074571
MISSION® esiRNA, targeting human VHL,
Species
human
EMU012571
MISSION® esiRNA, targeting mouse Vhl,
Species
mouse