UPF1
UPF1 regulator of nonsense transcripts homolog (yeast)
Synonyms:
HUPF1, NORF1, RENT1, pNORF1, smg-2
Species:
Human UPF1 (5976), Mouse Upf1 (19704), Rat Upf1 (684558), Horse UPF1 (100071059), cow UPF1 (532933), Zebrafish upf1 (406783), chicken UPF1 (420119), domestic cat UPF1 (101096043), naked mole-rat Upf1 (101704366), fruit fly Upf1 (32153) ...More
UniProtKB ID:
Gene ID:
- Human(5976) Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008]
- Mouse(19704) UPF1 regulator of nonsense transcripts homolog (yeast)
- Rat(684558) UPF1 regulator of nonsense transcripts homolog (yeast)
- Horse(100071059) UPF1 regulator of nonsense transcripts homolog (yeast)
- cow(532933) UPF1 regulator of nonsense transcripts homolog (yeast)
- Zebrafish(406783) upf1 regulator of nonsense transcripts homolog (yeast)
- chicken(420119) UPF1 regulator of nonsense transcripts homolog (yeast)
- domestic cat(101096043) UPF1 regulator of nonsense transcripts homolog (yeast)
- naked mole-rat(101704366) UPF1 regulator of nonsense transcripts homolog (yeast)
- fruit fly(32153) CG1559 gene product from transcript CG1559-RA
- sheep(101107598) UPF1 regulator of nonsense transcripts homolog (yeast)
- dog(476664) UPF1 regulator of nonsense transcripts homolog (yeast)
- domestic guinea pig(100713813) UPF1 regulator of nonsense transcripts homolog (yeast)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Upf1 Antibody, from rabbit,
Species Reactivity
bovine, canine, human, mouse, rat
Application
western blot
Anti-UPF1/RENT1 Antibody, clone 5D5C4, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunofluorescence
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-p-Upf1 (Ser1127) Antibody, clone 1C4-H1 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
affinity binding assay
immunocytochemistry
inhibition assay
western blot
immunocytochemistry
inhibition assay
western blot
Anti-phospho-Upf1 (Ser1127) Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
bovine, chicken, human, mouse, rat, yeast, zebrafish
Application
immunoprecipitation (IP)
western blot
western blot