TNK2
tyrosine kinase, non-receptor, 2
Synonyms:
ACK, ACK-1, ACK1, p21cdc42Hs
Species:
Human TNK2 (10188), Mouse Tnk2 (51789), Rat Tnk2 (303882), naked mole-rat Tnk2 (101701156), sheep TNK2 (101122917), cow TNK2 (280710), domestic guinea pig Tnk2 (100715920), domestic cat TNK2 (101098817), chicken TNK2 (431014), dog TNK2 (488025)
UniProtKB ID:
Gene ID:
- Human(10188) Summary: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
- Mouse(51789) tyrosine kinase, non-receptor, 2
- Rat(303882) tyrosine kinase, non-receptor, 2
- naked mole-rat(101701156) tyrosine kinase, non-receptor, 2
- sheep(101122917) tyrosine kinase, non-receptor, 2
- cow(280710) tyrosine kinase, non-receptor, 2
- domestic guinea pig(100715920) tyrosine kinase, non-receptor, 2
- domestic cat(101098817) tyrosine kinase, non-receptor, 2
- chicken(431014) tyrosine kinase, non-receptor, 2
- dog(488025) tyrosine kinase, non-receptor, 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-ACK1 (Tyr284) Antibody, Upstate®, from rabbit,
Species Reactivity
human
Application
dot blot
inhibition assay
western blot
inhibition assay
western blot
Anti-Tnk2 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence