SENP6
SUMO1/sentrin specific peptidase 6
Synonyms:
SSP1, SUSP1
Species:
Human SENP6 (26054), Mouse Senp6 (215351), Rat Senp6 (300860), Domestic Rabbit SENP6 (100353104), domestic guinea pig Senp6 (100715646), naked mole-rat Senp6 (101720383), chicken SENP6 (421859), dog SENP6 (481883), domestic cat SENP6 (101094508), Horse SENP6 (100068828) ...More
UniProtKB ID:
Gene ID:
- Human(26054) Summary: Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]
- Mouse(215351) SUMO/sentrin specific peptidase 6
- Rat(300860) SUMO1/sentrin specific peptidase 6
- Domestic Rabbit(100353104) SUMO1/sentrin specific peptidase 6
- domestic guinea pig(100715646) SUMO1/sentrin specific peptidase 6
- naked mole-rat(101720383) SUMO1/sentrin specific peptidase 6
- chicken(421859) SUMO1/sentrin specific peptidase 6
- dog(481883) SUMO1/sentrin specific peptidase 6
- domestic cat(101094508) SUMO1/sentrin specific peptidase 6
- Horse(100068828) SUMO1/sentrin specific peptidase 6
- cow(533853) SUMO1/sentrin specific peptidase 6
- sheep(101118793) SUMO1/sentrin specific peptidase 6
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