SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
Synonyms:
NAV1.9, NaN, SCN12A, SNS-2
Species:
Human SCN11A (11280), Mouse Scn11a (24046), Rat Scn11a (29701), domestic guinea pig Scn11a (100734219), Domestic Rabbit SCN11A (100349709), sheep SCN11A (101117022), cow SCN11A (535956), domestic cat SCN11A (101085312), dog SCN11A (485593), naked mole-rat Scn11a (101723747)
UniProtKB ID:
Gene ID:
- Human(11280) Summary: Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004]
- Mouse(24046) sodium channel, voltage-gated, type XI, alpha
- Rat(29701) sodium channel, voltage-gated, type XI, alpha subunit
- domestic guinea pig(100734219) sodium channel, voltage-gated, type XI, alpha subunit
- Domestic Rabbit(100349709) sodium channel, voltage-gated, type XI, alpha subunit
- sheep(101117022) sodium channel, voltage-gated, type XI, alpha subunit
- cow(535956) sodium channel, voltage-gated, type XI, alpha subunit
- domestic cat(101085312) sodium channel, voltage-gated, type XI, alpha subunit
- dog(485593) sodium channel, voltage-gated, type XI, alpha subunit
- naked mole-rat(101723747) sodium channel, voltage-gated, type XI, alpha subunit
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