RNASEH2A
ribonuclease H2, subunit A
Synonyms:
AGS4, JUNB, RNASEHI, RNHIA, RNHL
Species:
Human RNASEH2A (10535), Mouse Rnaseh2a (69724), Rat Rnaseh2a (364974), dog RNASEH2A (484925), naked mole-rat Rnaseh2a (101714999), domestic guinea pig Rnaseh2a (100715505), Goat RNASEH2A (100860936), cow RNASEH2A (512830), Zebrafish rnaseh2a (393195), domestic cat RNASEH2A (101086121)
UniProtKB ID:
Gene ID:
- Human(10535) Summary: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]
- Mouse(69724) ribonuclease H2, large subunit
- Rat(364974) ribonuclease H2, subunit A
- dog(484925) ribonuclease H2, subunit A
- naked mole-rat(101714999) ribonuclease H2, subunit A
- domestic guinea pig(100715505) ribonuclease H2, subunit A
- Goat(100860936) ribonuclease H2, subunit A
- cow(512830) ribonuclease H2, subunit A
- Zebrafish(393195) ribonuclease H2, subunit A
- domestic cat(101086121) ribonuclease H2, subunit A
- sheep(101105746) ribonuclease H2, subunit A
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