PTPN11
protein tyrosine phosphatase, non-receptor type 11
Synonyms:
BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Species:
Human PTPN11 (5781), Mouse Ptpn11 (19247), Rat Ptpn11 (25622), sheep PTPN11 (101114308), naked mole-rat Ptpn11 (101701336), dog PTPN11 (477488), domestic cat PTPN11 (101085500), chicken PTPN11 (395815), Horse PTPN11 (100056857), cow PTPN11 (533590)
UniProtKB ID:
Gene ID:
- Human(5781) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
- Mouse(19247) protein tyrosine phosphatase, non-receptor type 11
- Rat(25622) protein tyrosine phosphatase, non-receptor type 11
- sheep(101114308) protein tyrosine phosphatase, non-receptor type 11
- naked mole-rat(101701336) protein tyrosine phosphatase, non-receptor type 11
- dog(477488) protein tyrosine phosphatase, non-receptor type 11
- domestic cat(101085500) protein tyrosine phosphatase, non-receptor type 11
- chicken(395815) protein tyrosine phosphatase, non-receptor type 11
- Horse(100056857) protein tyrosine phosphatase, non-receptor type 11
- cow(533590) protein tyrosine phosphatase, non-receptor type 11
- domestic guinea pig(100732797) protein tyrosine phosphatase, non-receptor type 11
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SHP2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-SHP2 Antibody, clone 3B17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, canine, horse, human, monkey, porcine, rat
Application
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Proteins
Product Number
Description
Species