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Merck

PSMC3

proteasome (prosome, macropain) 26S subunit, ATPase, 3

Synonyms:
TBP1
Species:
UniProtKB ID:
Gene ID:
  • Human(5702) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]
  • Mouse(19182) proteasome (prosome, macropain) 26S subunit, ATPase 3
  • Rat(29677) proteasome (prosome, macropain) 26S subunit, ATPase 3
  • Zebrafish(321947) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • chicken(423182) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • domestic guinea pig(100727371) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • naked mole-rat(101706267) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • sheep(101117873) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • Domestic Rabbit(100354000) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • cow(508448) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • Horse(100051468) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • domestic cat(101095435) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • dog(475980) proteasome (prosome, macropain) 26S subunit, ATPase, 3

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esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PSMC3,
Species
human
MISSION® esiRNA, targeting mouse Psmc3,
Species
mouse