PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
Synonyms:
ALDD, D6S216, D6S216E, JMP, LMP7, NKJO, PSMB5i, RING10
Species:
Human PSMB8 (5696), Mouse Psmb8 (16913), Rat Psmb8 (24968), cow PSMB8 (282013), naked mole-rat Psmb8 (101702300), domestic cat PSMB8 (101083171), Zebrafish psmb8 (30666), sheep PSMB8 (100174905), Goat PSMB8 (100860993), domestic guinea pig Psmb8 (100717290)
UniProtKB ID:
Gene ID:
- Human(5696) Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008]
- Mouse(16913) proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
- Rat(24968) proteasome (prosome, macropain) subunit, beta type, 8
- cow(282013) proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
- naked mole-rat(101702300) proteasome (prosome, macropain) subunit, beta type, 8
- domestic cat(101083171) proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
- Zebrafish(30666) proteasome (prosome, macropain) subunit, beta type, 8
- sheep(100174905) proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
- Goat(100860993) proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
- domestic guinea pig(100717290) proteasome (prosome, macropain) subunit, beta type, 8
- dog(474865) proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
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