PLAT
plasminogen activator, tissue
Synonyms:
T-PA, TPA
Species:
Human PLAT (5327), Mouse Plat (18791), Rat Plat (25692), naked mole-rat Plat (101713266), domestic guinea pig Plat (100725281), cow PLAT (281407), sheep PLAT (101118332), chicken PLAT (426791), domestic cat PLAT (101100299), Horse PLAT (100050239) ...More
UniProtKB ID:
Gene ID:
- Human(5327) Summary: This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(18791) plasminogen activator, tissue
- Rat(25692) plasminogen activator, tissue
- naked mole-rat(101713266) plasminogen activator, tissue
- domestic guinea pig(100725281) plasminogen activator, tissue
- cow(281407) plasminogen activator, tissue
- sheep(101118332) plasminogen activator, tissue
- chicken(426791) plasminogen activator, tissue
- domestic cat(101100299) plasminogen activator, tissue
- Horse(100050239) plasminogen activator, tissue
- dog(482840) plasminogen activator, tissue
- Zebrafish(100320028) plasminogen activator, tissue
- Domestic Rabbit(100009556) plasminogen activator, tissue
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Tissue Plasminogen Activator (Ab-1) Mouse mAb (GMA-043), liquid, clone GMA-043, Calbiochem®,
Species Reactivity
human
Application
Anti-tPA/PLAT antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-tPA (Tissue Plasminogen Activator) Antibody, clone GMA-043, clone GMA-043, Upstate®, from mouse,
Species Reactivity
human
Application
ELISA
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Aminocaproic acid, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Proteins
Product Number
Description
Species