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Merck

PIK3R1

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Synonyms:
AGM7, GRB1, p85, p85-ALPHA
Species:
Human PIK3R1 (5295), Mouse Pik3r1 (18708), Rat Pik3r1 (25513), domestic guinea pig Pik3r1 (100730242), domestic cat PIK3R1 (100271864), cow PIK3R1 (282307), sheep PIK3R1 (101121455), chicken PIK3R1 (427171), Zebrafish pik3r1 (557176), dog PIK3R1 (487235)
UniProtKB ID:
P27986, B3KT19, D3DWA0, E7EX19, Q15747, Q4VBZ7, Q53EM6, Q8IXA2
Gene ID:
  • Human(5295) Summary: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
  • Mouse(18708) phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
  • Rat(25513) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • domestic guinea pig(100730242) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • domestic cat(100271864) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • cow(282307) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • sheep(101121455) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • chicken(427171) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • Zebrafish(557176) phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)
  • dog(487235) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
ZRB1898
Anti-PI3-Kinase p85α Antibody, clone 3D12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, canine, feline, human, monkey, mouse, porcine, rat
Application
affinity binding assay
immunohistochemistry
western blot
SAB5702438
Anti-PI3 Kinase p85 alpha Antibody, clone 7Z9H0, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot
05-212
Anti-PI3 Kinase Antibody, p85, N-SH3, clone AB6, clone AB6, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
MABS831
Anti-PI3 Kinase Antibody, p85 Antibody, N-SH3 Antibody, clone 1D5.1, clone 1D5.1, from mouse,
Species Reactivity
human, mouse
Application
western blot
ABS233
Anti-PI3 Kinase p85 Antibody, N-SH2 domain, from rabbit, purified by affinity chromatography,
Species Reactivity
bovine, human, monkey, mouse, rat
Application
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
W3144
Wortmannin, Ready Made Solution, from Penicillium funiculosum, ≥95% (HPLC),
Species
human
W1628
Wortmannin, from Penicillium funiculosum, ≥98% (HPLC and TLC),
Species
human
D2926
Diphenyleneiodonium chloride, ≥98%,
Species
mouse, human
PZ0235
PF-04691502, ≥98% (HPLC),
Species
human

esiRNA

Product Number
Description
Species
EHU151811
MISSION® esiRNA, targeting human PIK3R1,
Species
human
EMU187151
MISSION® esiRNA, targeting mouse Pik3r1,
Species
mouse