PIK3C2A
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Synonyms:
CPK, PI3-K-C2(ALPHA), PI3-K-C2A
Species:
Human PIK3C2A (5286), Mouse Pik3c2a (18704), Rat Pik3c2a (361632), sheep PIK3C2A (101114899), Zebrafish pik3c2a (571356), domestic cat PIK3C2A (101096512), cow PIK3C2A (537790), chicken PIK3C2A (423070), naked mole-rat Pik3c2a (101702206), Domestic Rabbit PIK3C2A (100340704) ...More
UniProtKB ID:
Gene ID:
- Human(5286) Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]
- Mouse(18704) phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
- Rat(361632) phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
- sheep(101114899) phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
- Zebrafish(571356) phosphoinositide-3-kinase, class 2, alpha polypeptide
- domestic cat(101096512) phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
- cow(537790) phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
- chicken(423070) phosphoinositide-3-kinase, class 2, alpha polypeptide
- naked mole-rat(101702206) phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
- Domestic Rabbit(100340704) phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
- Horse(100056431) phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
- dog(485399) phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
- domestic guinea pig(100722144) phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
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