PEG3
paternally expressed 3
Synonyms:
PW1, ZKSCAN22, ZNF904, ZSCAN24
Species:
Human PEG3 (5178), Mouse Peg3 (18616), Rat Peg3 (246361), dog PEG3 (476371), sheep PEG3 (100505405), domestic cat PEG3 (100510800), cow PEG3 (444864), naked mole-rat Peg3 (101714488), sheep PEG3 (101112254)
UniProtKB ID:
Gene ID:
- Human(5178) Summary: In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
- Mouse(18616) paternally expressed 3
- Rat(246361) paternally expressed 3
- dog(476371) paternally expressed 3
- sheep(100505405) paternally expressed 3
- domestic cat(100510800) paternally expressed 3
- cow(444864) paternally expressed 3
- naked mole-rat(101714488) paternally expressed 3
- sheep(101112254) paternally expressed 3
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