PCDHA9
protocadherin alpha 9
Synonyms:
PCDH-ALPHA9
Species:
Human PCDHA9 (9752), Mouse Pcdha9 (192161), Rat Pcdha9 (393090), domestic guinea pig Pcdha9 (100714706), chicken PCDHA9 (497219), dog PCDHA9 (487165), cow PCDHA9 (539540), cow PCDHA9 (616121)
UniProtKB ID:
Gene ID:
- Human(9752) Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
- Mouse(192161) protocadherin alpha 9
- Rat(393090) protocadherin alpha 9
- domestic guinea pig(100714706) protocadherin alpha 9
- chicken(497219) protocadherin alpha 9
- dog(487165) protocadherin alpha 9
- cow(539540) protocadherin alpha 9
- cow(616121) protocadherin alpha 9
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