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Merck

PCDHA1

protocadherin alpha 1

Synonyms:
PCDH-ALPHA1
Species:
UniProtKB ID:
Gene ID:
  • Human(56147) Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
  • Mouse(116731) protocadherin alpha 1
  • Rat(393085) protocadherin alpha 1
  • domestic cat(101092233) protocadherin alpha 1
  • chicken(497211) protocadherin alpha 1
  • cow(100847114) protocadherin alpha 1
  • sheep(101122108) protocadherin alpha 1
  • domestic guinea pig(100712773) protocadherin alpha 1
  • naked mole-rat(101724810) protocadherin alpha 1

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esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PCDHA1,
Species
human
MISSION® esiRNA, targeting mouse Pcdha1,
Species
mouse