OPTN
optineurin
Synonyms:
ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
Species:
Human OPTN (10133), Mouse Optn (71648), Rat Optn (246294), domestic guinea pig Optn (100722896), naked mole-rat Optn (101725616), domestic cat OPTN (101087414), cow OPTN (534150), sheep OPTN (101106703), chicken OPTN (374079), dog OPTN (478003)
UniProtKB ID:
Gene ID:
- Human(10133) Summary: This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
- Mouse(71648) optineurin
- Rat(246294) optineurin
- domestic guinea pig(100722896) optineurin
- naked mole-rat(101725616) optineurin
- domestic cat(101087414) optineurin
- cow(534150) optineurin
- sheep(101106703) optineurin
- chicken(374079) optineurin
- dog(478003) optineurin
- Zebrafish(336159) optineurin
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