NOTCH1
notch 1
Synonyms:
TAN1, hN1
Species:
Human NOTCH1 (4851), Mouse Notch1 (18128), Rat Notch1 (25496), cow NOTCH1 (767866), chicken NOTCH1 (395655), dog NOTCH1 (480676), sheep NOTCH1 (101115020), naked mole-rat Notch1 (101704336), domestic cat NOTCH1 (101094384), Horse NOTCH1 (100068764)
UniProtKB ID:
Gene ID:
- Human(4851) Summary: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008]
- Mouse(18128) notch 1
- Rat(25496) notch 1
- cow(767866) notch 1
- chicken(395655) notch 1
- dog(480676) notch 1
- sheep(101115020) notch 1
- naked mole-rat(101704336) notch 1
- domestic cat(101094384) notch 1
- Horse(100068764) notch 1
- domestic guinea pig(100724583) notch 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Notch1 Antibody, Intracellular, serum, from rabbit,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti- Notch1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-Notch 1 Antibody, extracellular, clone 8G10, culture supernatant, clone 8G10, Chemicon®,
Species Reactivity
mouse, rat
Application
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Notch 1 Antibody, clone mN1A, clone mN1A, Chemicon®, from mouse,
Species Reactivity
feline, mouse, rat
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Notch 1 Antibody, NT, serum, from rabbit,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot