NLRP11
NLR family, pyrin domain containing 11
Synonyms:
CLR19.6, NALP11, NOD17, PAN10, PYPAF6, PYPAF7
Species:
UniProtKB ID:
Gene ID:
- Human(204801) Summary: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]
- Domestic Rabbit(100349718) NLR family, pyrin domain containing 11
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