MCM10
minichromosome maintenance complex component 10
Synonyms:
CNA43, DNA43
Species:
Human MCM10 (55388), Mouse Mcm10 (70024), Rat Mcm10 (307126), Domestic Rabbit MCM10 (100343921), domestic cat MCM10 (101097738), cow MCM10 (527595), chicken MCM10 (429525), naked mole-rat Mcm10 (101725983), dog MCM10 (487128), domestic guinea pig Mcm10 (100724190) ...More
UniProtKB ID:
Gene ID:
- Human(55388) Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
- Mouse(70024) minichromosome maintenance deficient 10 (S. cerevisiae)
- Rat(307126) minichromosome maintenance complex component 10
- Domestic Rabbit(100343921) minichromosome maintenance complex component 10
- domestic cat(101097738) minichromosome maintenance complex component 10
- cow(527595) minichromosome maintenance complex component 10
- chicken(429525) minichromosome maintenance complex component 10
- naked mole-rat(101725983) minichromosome maintenance complex component 10
- dog(487128) minichromosome maintenance complex component 10
- domestic guinea pig(100724190) minichromosome maintenance complex component 10
- Zebrafish(553396) minichromosome maintenance complex component 10
- Thale Cress(816632) minichromosome maintenance protein 10
- sheep(101106958) minichromosome maintenance complex component 10
- fruit fly(35390) Sensitized chromosome inheritance modifier 19
- Horse(100069273) minichromosome maintenance complex component 10
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