LTB
lymphotoxin beta (TNF superfamily, member 3)
Synonyms:
TNFC, TNFSF3, p33
Species:
Human LTB (4050), Mouse Ltb (16994), Rat Ltb (361795), domestic cat LTB (101085208), dog LTB (481712), sheep LTB (101122820), cow LTB (529757), naked mole-rat Ltb (101716941), domestic guinea pig Ltb (100722556)
UniProtKB ID:
Gene ID:
- Human(4050) Summary: Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(16994) lymphotoxin B
- Rat(361795) lymphotoxin beta (TNF superfamily, member 3)
- domestic cat(101085208) lymphotoxin beta (TNF superfamily, member 3)
- dog(481712) lymphotoxin beta (TNF superfamily, member 3)
- sheep(101122820) lymphotoxin beta (TNF superfamily, member 3)
- cow(529757) lymphotoxin beta (TNF superfamily, member 3)
- naked mole-rat(101716941) lymphotoxin beta (TNF superfamily, member 3)
- domestic guinea pig(100722556) lymphotoxin beta (TNF superfamily, member 3)
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