LAMC1
laminin, gamma 1 (formerly LAMB2)
Synonyms:
LAMB2
Species:
Human LAMC1 (3915), Mouse Lamc1 (226519), Rat Lamc1 (117036), Zebrafish lamc1 (286832), dog LAMC1 (480034), chicken LAMC1 (424442), Horse LAMC1 (100053539), naked mole-rat Lamc1 (101720256), domestic cat LAMC1 (101090321), sheep LAMC1 (101105588) ...More
UniProtKB ID:
Gene ID:
- Human(3915) Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. [provided by RefSeq, Aug 2011]
- Mouse(226519) laminin, gamma 1
- Rat(117036) laminin, gamma 1
- Zebrafish(286832) laminin, gamma 1
- dog(480034) laminin, gamma 1 (formerly LAMB2)
- chicken(424442) laminin, gamma 1 (formerly LAMB2)
- Horse(100053539) laminin, gamma 1 (formerly LAMB2)
- naked mole-rat(101720256) laminin, gamma 1 (formerly LAMB2)
- domestic cat(101090321) laminin, gamma 1 (formerly LAMB2)
- sheep(101105588) laminin, gamma 1 (formerly LAMB2)
- Domestic Rabbit(100009388) laminin, gamma 1 (formerly LAMB2)
- cow(532572) laminin, gamma 1 (formerly LAMB2)
- domestic guinea pig(100734278) laminin, gamma 1 (formerly LAMB2)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Laminin γ1 Antibody, clone 2E8 (Ascites Free), clone 2E8, from mouse,
Species Reactivity
feline, human, mouse, rat
Application
ELISA
immunocytochemistry
immunofluorescence
western blot
immunocytochemistry
immunofluorescence
western blot
Anti-Laminin γ1 Antibody, clone 2E8, ascites fluid, clone 2E8, Chemicon®,
Species Reactivity
human, rat
Application
ELISA
cell culture | mammalian
immunohistochemistry
immunoprecipitation (IP)
western blot
cell culture | mammalian
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Laminin gamma 1 Antibody, clone A5, clone A5, Chemicon®, from rat,
Species Reactivity
human, mouse
Application
immunohistochemistry
Proteins
Product Number
Description
Species
Laminin from Engelbreth-Holm-Swarm murine sarcoma basement membrane, 1-2 mg/mL in Tris-buffered saline, 0.2 μm filtered, BioReagent, suitable for cell culture,
Species
mouse
ECM Gel from Engelbreth-Holm-Swarm murine sarcoma, liquid, BioReagent, suitable for cell culture,
Species
mouse
ECM Gel from Engelbreth-Holm-Swarm murine sarcoma, growth-factor reduced, without phenol red, liquid, BioReagent, suitable for cell culture,
Species
mouse