KREMEN2
kringle containing transmembrane protein 2
Synonyms:
KRM2
Species:
Human KREMEN2 (79412), Mouse Kremen2 (73016), Rat Kremen2 (287102), naked mole-rat Kremen2 (101720049), domestic cat KREMEN2 (101098677), sheep KREMEN2 (101119273), domestic guinea pig Kremen2 (100734476), cow KREMEN2 (618527), dog KREMEN2 (610753)
UniProtKB ID:
Gene ID:
- Human(79412) Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
- Mouse(73016) kringle containing transmembrane protein 2
- Rat(287102) kringle containing transmembrane protein 2
- naked mole-rat(101720049) kringle containing transmembrane protein 2
- domestic cat(101098677) kringle containing transmembrane protein 2
- sheep(101119273) kringle containing transmembrane protein 2
- domestic guinea pig(100734476) kringle containing transmembrane protein 2
- cow(618527) kringle containing transmembrane protein 2
- dog(610753) kringle containing transmembrane protein 2
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