KPNB1
karyopherin (importin) beta 1
Synonyms:
IMB1, IPO1, IPOB, Impnb, NTF97
Species:
Human KPNB1 (3837), Mouse Kpnb1 (16211), Rat Kpnb1 (24917), naked mole-rat Kpnb1 (101726701), sheep KPNB1 (101118967), domestic guinea pig Kpnb1 (100723526), Zebrafish kpnb1 (570700), Domestic Rabbit KPNB1 (100353372), dog KPNB1 (491042), Horse KPNB1 (100069121) ...More
UniProtKB ID:
Gene ID:
- Human(3837) Summary: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
- Mouse(16211) karyopherin (importin) beta 1
- Rat(24917) karyopherin (importin) beta 1
- naked mole-rat(101726701) karyopherin (importin) beta 1
- sheep(101118967) karyopherin (importin) beta 1
- domestic guinea pig(100723526) karyopherin (importin) beta 1
- Zebrafish(570700) karyopherin (importin) beta 1
- Domestic Rabbit(100353372) karyopherin (importin) beta 1
- dog(491042) karyopherin (importin) beta 1
- Horse(100069121) karyopherin (importin) beta 1
- chicken(426499) karyopherin (importin) beta 1
- cow(507804) karyopherin (importin) beta 1
- domestic cat(101086517) karyopherin (importin) beta 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Importin beta-1 Antibody, clone 3H14, clone 3H14, from mouse,
Species Reactivity
human
Application
immunocytochemistry
western blot
western blot