HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
Synonyms:
11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1
Species:
Human HSD11B1 (3290), Mouse Hsd11b1 (15483), Rat Hsd11b1 (25116), domestic cat HSD11B1 (100529248), dog HSD11B1 (449023), domestic guinea pig Hsd11b1 (100135542), cow HSD11B1 (282589), sheep HSD11B1 (443409), naked mole-rat Hsd11b1 (101716800), chicken HSD11B1 (419861)
UniProtKB ID:
Gene ID:
- Human(3290) Summary: The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]
- Mouse(15483) hydroxysteroid 11-beta dehydrogenase 1
- Rat(25116) hydroxysteroid 11-beta dehydrogenase 1
- domestic cat(100529248) hydroxysteroid (11-beta) dehydrogenase 1
- dog(449023) hydroxysteroid (11-beta) dehydrogenase 1
- domestic guinea pig(100135542) hydroxysteroid 11-beta dehydrogenase 1
- cow(282589) hydroxysteroid (11-beta) dehydrogenase 1
- sheep(443409) hydroxysteroid (11-beta) dehydrogenase 1
- naked mole-rat(101716800) hydroxysteroid (11-beta) dehydrogenase 1
- chicken(419861) hydroxysteroid (11-beta) dehydrogenase 1
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