HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
Synonyms:
DFNB39, F-TCF, HGFB, HPTA, SF
Species:
Human HGF (3082), Mouse Hgf (15234), Rat Hgf (24446), cow HGF (282879), sheep HGF (443075), Domestic Rabbit HGF (100316908), domestic guinea pig Hgf (100730730), naked mole-rat Hgf (101707056), chicken HGF (395941), dog HGF (403441)
UniProtKB ID:
Gene ID:
- Human(3082) Summary: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(15234) hepatocyte growth factor
- Rat(24446) hepatocyte growth factor
- cow(282879) hepatocyte growth factor (hepapoietin A; scatter factor)
- sheep(443075) hepatocyte growth factor (hepapoietin A; scatter factor)
- Domestic Rabbit(100316908) hepatocyte growth factor (hepapoietin A; scatter factor)
- domestic guinea pig(100730730) hepatocyte growth factor (hepapoietin A; scatter factor)
- naked mole-rat(101707056) hepatocyte growth factor (hepapoietin A; scatter factor)
- chicken(395941) hepatocyte growth factor (hepapoietin A; scatter factor)
- dog(403441) hepatocyte growth factor (hepapoietin A; scatter factor)
- domestic cat(493705) hepatocyte growth factor (hepapoietin A; scatter factor)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-c-Met Antibody, clone seeMet 13, clone seeMet 13, from mouse,
Species Reactivity
human
Application
flow cytometry
immunocytochemistry
immunoprecipitation (IP)
inhibition assay
immunocytochemistry
immunoprecipitation (IP)
inhibition assay
Anti-HGF (Scatter Factor) (Ab-1) Mouse mAb (4C12.1), liquid, clone 4C12.1, Calbiochem®,
Species Reactivity
human
Application
Proteins
Product Number
Description
Species
Hepatocyte Growth Factor human, HGF, recombinant, expressed in Baculovirus infected High-5 cells, suitable for cell culture,
Species
human
Hepatocyte Growth Factor human, HGF, recombinant, expressed in NSO cells, suitable for cell culture,
Species
human
Hepatocyte Growth Factor human, HGF, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture,
Species
human
HGF mouse, recombinant, expressed in Hi-5 Insect cells, ≥95% (SDS-PAGE), ≥95% (HPLC),
Species
mouse
