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Merck

CYP11A1

cytochrome P450, family 11, subfamily A, polypeptide 1

Synonyms:
CYP11A, CYPXIA1, P450SCC
Species:
Human CYP11A1 (1583), Mouse Cyp11a1 (13070), Rat Cyp11a1 (29680), sheep CYP11A1 (100048994), Domestic Rabbit CYP11A1 (100345737), cow CYP11A1 (338048), Zebrafish cyp11a1 (80374), chicken CYP11A1 (414838), Horse CYP11A1 (100034229), dog CYP11A1 (478365)
UniProtKB ID:
P05108, A8K8D5, B3KPU8, G3XAD7, Q15081, Q16805, Q8N1A7
Gene ID:
  • Human(1583) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
  • Mouse(13070) cytochrome P450, family 11, subfamily a, polypeptide 1
  • Rat(29680) cytochrome P450, family 11, subfamily a, polypeptide 1
  • sheep(100048994) cytochrome P450, family 11, subfamily A, polypeptide 1
  • Domestic Rabbit(100345737) cytochrome P450, family 11, subfamily A, polypeptide 1
  • cow(338048) cytochrome P450, family 11, subfamily A, polypeptide 1
  • Zebrafish(80374) cytochrome P450, subfamily XIA, polypeptide 1
  • chicken(414838) cytochrome P450, family 11, subfamily A, polypeptide 1
  • Horse(100034229) cytochrome P450 cholesterol side-chain cleavage
  • dog(478365) cytochrome P450, family 11, subfamily A, polypeptide 1

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Antibodies

Product Number
Description
Species Reactivity
Application
ZRB2822
Anti-CYP11A1 Antibody, clone 2M5 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
chimpanzee, human
Application
affinity binding assay
immunofluorescence
immunohistochemistry
western blot
ABS236
Anti-Cytochrome P450 (scc) Antibody, a.a. 509-526, from rabbit, purified by affinity chromatography,
Species Reactivity
rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
1445007
Mitotane, United States Pharmacopeia (USP) Reference Standard,
Species
human
35485
2,4′-DDD, PESTANAL®, analytical standard,
Species
human
44012
1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland,
Species
human

esiRNA

Product Number
Description
Species
EHU143581
MISSION® esiRNA, targeting human CYP11A1,
Species
human
EMU079961
MISSION® esiRNA, targeting mouse Cyp11a1,
Species
mouse