CTSL
cathepsin L
Synonyms:
CATL, CTSL1, MEP
Species:
UniProtKB ID:
Gene ID:
- Human(1514) Summary: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
- Mouse(13039) cathepsin L
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Cathepsin L/V/K/H Antibody, clone 2Q10F10, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot
western blot
Anti-CTSL antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Proteins
Product Number
Description
Species
Cathepsin L, Human Liver, Cathepsin L, Human Liver, CAS 60616-82-2, is a native, the most potent of all the lysosomal proteinases. Plays a major role in the proteolysis of both cellular and endocytosed macromolecules.,
Species
human
esiRNA
Product Number
Description
Species