CHMP4B
charged multivesicular body protein 4B
Synonyms:
C20orf178, CHMP4A, CTPP3, CTRCT31, SNF7, SNF7-2, Shax1, VPS32B, Vps32-2, dJ553F4.4
Species:
Human CHMP4B (128866), Mouse Chmp4b (75608), Rat Chmp4b (100359642), domestic guinea pig Chmp4b (100714567), domestic cat CHMP4B (101097964), Zebrafish chmp4b (406766), chicken CHMP4B (419150), dog CHMP4B (485842), sheep CHMP4B (101111216), cow CHMP4B (616164)
UniProtKB ID:
Gene ID:
- Human(128866) Summary: This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]
- Mouse(75608) charged multivesicular body protein 4B
- Rat(100359642) charged multivesicular body protein 4B
- domestic guinea pig(100714567) charged multivesicular body protein 4B
- domestic cat(101097964) charged multivesicular body protein 4B
- Zebrafish(406766) chromatin modifying protein 4B
- chicken(419150) chromatin modifying protein 4B
- dog(485842) charged multivesicular body protein 4B
- sheep(101111216) charged multivesicular body protein 4B
- cow(616164) charged multivesicular body protein 4B
- naked mole-rat(101716032) charged multivesicular body protein 4B
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