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Merck

CDK1

cyclin-dependent kinase 1

Synonyms:
CDC2, CDC28A, P34CDC2
Species:
UniProtKB ID:
Gene ID:
  • Human(983) Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
  • Mouse(12534) cyclin-dependent kinase 1
  • Rat(54237) cyclin-dependent kinase 1
  • dog(488997) cyclin-dependent kinase 1
  • Zebrafish(80973) cyclin-dependent kinase 1
  • chicken(396252) cyclin-dependent kinase 1
  • naked mole-rat(101717463) cyclin-dependent kinase 1
  • domestic guinea pig(100735946) cyclin-dependent kinase 1
  • Goat(100861361) cyclin-dependent kinase 1
  • cow(281061) cyclin-dependent kinase 1
  • sheep(100216432) cyclin-dependent kinase 1

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Phospho-CDK1-Y15 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-Cdk1 Antibody, clone A17.1.1, clone A17.1.1, Chemicon®, from mouse,
Species Reactivity
xenopus, chicken, human, mouse, rat
Application
activity assay
immunofluorescence

immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-phospho-Cdk1 (Thr14, Tyr15)Antibody, clone CP3.2, clone CP3.2, from mouse,
Species Reactivity
human
Application
immunocytochemistry
western blot
Anti-Cdc2 Antibody, phospho-specific (Tyr15), Chemicon®, from rabbit,
Species Reactivity
rat
Application
western blot
Anti-CDK1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
R547, ≥98% (HPLC),
Species
human
Flavopiridol hydrochloride hydrate, ≥98% (HPLC), powder,
Species
human
Roscovitine, ≥98% (TLC),
Species
human, mouse, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CDK1,
Species
human