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Merck

C8orf4

chromosome 8 open reading frame 4

Synonyms:
TC-1, TC1
Species:
Human C8orf4 (56892), chicken C8ORF4 (771032)
UniProtKB ID:
Q9NR00
Gene ID:
  • Human(56892) Summary: This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
  • chicken(771032) chromosome 22 open reading frame, human C8orf4

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