C4BPB
complement component 4 binding protein, beta
Synonyms:
C4BP
Species:
Human C4BPB (725), Rat C4bpb (24236), cow C4BPB (281652), domestic guinea pig C4bpb (100713956), dog C4BPB (609285), sheep C4BPB (101114204), naked mole-rat C4bpb (101720955), domestic cat C4BPB (101095148)
UniProtKB ID:
Gene ID:
- Human(725) Summary: This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]
- Rat(24236) complement component 4 binding protein, beta
- cow(281652) complement component 4 binding protein, beta
- domestic guinea pig(100713956) complement component 4 binding protein, beta
- dog(609285) complement component 4 binding protein, beta
- sheep(101114204) complement component 4 binding protein, beta
- naked mole-rat(101720955) complement component 4 binding protein, beta
- domestic cat(101095148) complement component 4 binding protein, beta
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