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Merck

BRCA2

breast cancer 2, early onset

Synonyms:
BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2
Species:
Human BRCA2 (675), Mouse Brca2 (12190), Rat Brca2 (360254), domestic guinea pig Brca2 (100713136), Zebrafish brca2 (566758), naked mole-rat Brca2 (101698015), chicken BRCA2 (374139), sheep BRCA2 (101109980), fruit fly Brca2 (37916), cow BRCA2 (507069) ...More
UniProtKB ID:
P51587, O00183, O15008, Q13879, Q5TBJ7
Gene ID:
  • Human(675) Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
  • Mouse(12190) breast cancer 2
  • Rat(360254) breast cancer 2, early onset
  • domestic guinea pig(100713136) breast cancer 2, early onset
  • Zebrafish(566758) breast cancer 2, early onset
  • naked mole-rat(101698015) breast cancer 2, early onset
  • chicken(374139) breast cancer 2, early onset
  • sheep(101109980) breast cancer 2, early onset
  • fruit fly(37916) Breast cancer 2, early onset homolog
  • cow(507069) breast cancer 2, early onset
  • dog(474180) breast cancer 2, early onset
  • domestic cat(493878) breast cancer 2, early onset
  • Horse(100064578) breast cancer 2, early onset

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Antibodies

Product Number
Description
Species Reactivity
Application
05-666
Anti-BRCA2 Antibody, clone 5.23, clone 5.23, Upstate®, from mouse,
Species Reactivity
human
Application
immunocytochemistry
western blot
OP95
Anti-BRCA2 (Ab-1) Mouse mAb (2B), liquid, clone 2B, Calbiochem®,
Species Reactivity
human
Application
ZRB2563
Anti-BRCA2 Antibody, clone 1H2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
AB9986
Anti-phospho-BRCA2 (Ser3291) Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
canine, cat, chimpanzee, equine, hamster, horse, human, mouse, rat, rhesus macaque, rhesus monkey
Application
dot blot
immunocytochemistry
immunohistochemistry

esiRNA

Product Number
Description
Species
EHU031451
MISSION® esiRNA, targeting human BRCA2,
Species
human
EMU075501
MISSION® esiRNA, targeting mouse Brca2,
Species
mouse