B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
Synonyms:
B4Gal-T2, B4Gal-T3, beta4Gal-T2
Species:
Human B4GALT2 (8704), Mouse B4galt2 (53418), Rat B4galt2 (313536), domestic guinea pig B4galt2 (100724702), chicken B4GALT2 (396122), Domestic Rabbit B4GALT2 (100351419), sheep B4GALT2 (101114825), cow B4GALT2 (100125390), Horse B4GALT2 (100066149), domestic cat B4GALT2 (101084809) ...More
UniProtKB ID:
Gene ID:
- Human(8704) Summary: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
- Mouse(53418) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
- Rat(313536) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
- domestic guinea pig(100724702) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
- chicken(396122) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
- Domestic Rabbit(100351419) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
- sheep(101114825) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
- cow(100125390) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
- Horse(100066149) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
- domestic cat(101084809) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
- dog(482527) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
- naked mole-rat(101718811) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
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