B4GALT1
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Synonyms:
B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1
Species:
Human B4GALT1 (2683), Mouse B4galt1 (14595), Rat B4galt1 (24390), chicken B4GALT1 (396121), Zebrafish b4galt1 (550425), naked mole-rat B4galt1 (101721414), sheep B4GALT1 (100620048), Goat B4GALT1 (100860927), cow B4GALT1 (281781), dog B4GALT1 (481579)
UniProtKB ID:
Gene ID:
- Human(2683) Summary: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008]
- Mouse(14595) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
- Rat(24390) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
- chicken(396121) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
- Zebrafish(550425) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
- naked mole-rat(101721414) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
- sheep(100620048) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
- Goat(100860927) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
- cow(281781) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
- dog(481579) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
- Domestic Rabbit(100345726) UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti- B4GALT1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot