ATP6V1C1
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
Synonyms:
ATP6C, ATP6D, VATC, Vma5
Species:
Human ATP6V1C1 (528), Mouse Atp6v1c1 (66335), Rat Atp6v1c1 (299971), cow ATP6V1C1 (338089), naked mole-rat Atp6v1c1 (101721955), sheep ATP6V1C1 (101122445), Domestic Rabbit ATP6V1C1 (100343886), chicken ATP6V1C1 (420259), domestic cat ATP6V1C1 (101084001), dog ATP6V1C1 (475061)
UniProtKB ID:
Gene ID:
- Human(528) Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008]
- Mouse(66335) ATPase, H+ transporting, lysosomal V1 subunit C1
- Rat(299971) ATPase, H+ transporting, lysosomal V1 subunit C1
- cow(338089) ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
- naked mole-rat(101721955) ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
- sheep(101122445) ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
- Domestic Rabbit(100343886) ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
- chicken(420259) ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
- domestic cat(101084001) ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
- dog(475061) ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
- domestic guinea pig(100725980) ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
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