ASIP
agouti signaling protein
Synonyms:
AGSW, AGTI, AGTIL, ASP, SHEP9
Species:
Human ASIP (434), Rat Asip (24152), cow ASIP (404192), Goat ASIP (100860915), Horse ASIP (100054335), domestic cat ASIP (492297), domestic guinea pig Asip (100721050), Zebrafish asip (798574), chicken ASIP (419147), Domestic Rabbit ASIP (100144328) ...More
UniProtKB ID:
Gene ID:
- Human(434) Summary: In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
- Rat(24152) agouti signaling protein
- cow(404192) agouti signaling protein
- Goat(100860915) agouti signaling protein
- Horse(100054335) agouti signaling protein
- domestic cat(492297) agouti signaling protein
- domestic guinea pig(100721050) agouti signaling protein
- Zebrafish(798574) agouti signaling protein
- chicken(419147) agouti signaling protein
- Domestic Rabbit(100144328) agouti signaling protein
- dog(492296) agouti signaling protein
- naked mole-rat(101713451) agouti signaling protein
- sheep(100127221) agouti signaling protein
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