Skip to Content
Merck

ARNT

aryl hydrocarbon receptor nuclear translocator

Synonyms:
HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2
Species:
Human ARNT (405), Mouse Arnt (11863), Rat Arnt (25242), dog ARNT (483185), domestic cat ARNT (101093627), domestic guinea pig Arnt (100379223), naked mole-rat Arnt (101717560), Zebrafish arnt (493634), sheep ARNT (443285), cow ARNT (281010)
UniProtKB ID:
P27540, C4AMA1, Q5QP39, Q8NDC7
Gene ID:
  • Human(405) Summary: The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
  • Mouse(11863) aryl hydrocarbon receptor nuclear translocator
  • Rat(25242) aryl hydrocarbon receptor nuclear translocator
  • dog(483185) aryl hydrocarbon receptor nuclear translocator
  • domestic cat(101093627) aryl hydrocarbon receptor nuclear translocator
  • domestic guinea pig(100379223) aryl hydrocarbon receptor nuclear translocator
  • naked mole-rat(101717560) aryl hydrocarbon receptor nuclear translocator
  • Zebrafish(493634) aryl hydrocarbon receptor nuclear translocator
  • sheep(443285) aryl hydrocarbon receptor nuclear translocator
  • cow(281010) aryl hydrocarbon receptor nuclear translocator
  • chicken(374026) aryl hydrocarbon receptor nuclear translocator

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
SAB5701257
Anti-HIF1β/ARNT antibody produced in rabbit, ,
Species Reactivity
human
Application
immunohistochemistry
western blot
ZRB1800
Anti-ARNT Antibody, clone 1H2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
canine, feline, human, monkey, mouse, porcine, rat
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot

esiRNA

Product Number
Description
Species
EMU072681
MISSION® esiRNA, targeting mouse Arnt,
Species
mouse
EHU083391
MISSION® esiRNA, targeting human ARNT,
Species
human