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Merck

APPL2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

Synonyms:
DIP13B
Species:
UniProtKB ID:
Gene ID:
  • Human(55198) Summary: The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
  • Mouse(216190) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
  • Rat(362860) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
  • dog(481297) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
  • domestic guinea pig(100717140) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
  • Zebrafish(100000135) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
  • cow(515605) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
  • domestic cat(101089119) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
  • cow(788375) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2-like
  • naked mole-rat(101696710) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
  • sheep(101114693) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
  • chicken(418075) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Appl2 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Appl2,
Species
mouse
MISSION® esiRNA, targeting human APPL2,
Species
human