- Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis.
Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis.
Nature communications (2017-11-01)
Liang Zhao, Chelsea L Thorsheim, Aae Suzuki, Timothy J Stalker, Sang H Min, Lurong Lian, Gregory D Fairn, Shamshad Cockcroft, Amy Durham, Sriram Krishnaswamy, Charles S Abrams
PMID29084966
ABSTRACT
Platelets are increasingly recognized for their contributions to tumor metastasis. Here, we show that the phosphoinositide signaling modulated by phosphatidylinositol transfer protein type α (PITPα), a protein which shuttles phosphatidylinositol between organelles, is essential for platelet-mediated tumor metastasis. PITPα-deficient platelets have reduced intracellular pools of phosphoinositides and an 80% reduction in IP