Skip to Content
Merck
  • A simple and efficient chemoselective method for the catalytic deprotection of acetals and ketals using bismuth triflate.

A simple and efficient chemoselective method for the catalytic deprotection of acetals and ketals using bismuth triflate.

The Journal of organic chemistry (2002-02-22)
Marc D Carrigan, Dusan Sarapa, Russell C Smith, Laura C Wieland, Ram S Mohan
ABSTRACT

Bismuth triflate is a highly efficient catalyst (0.1-1 mol %) for the deprotection of acetals and ketals. The procedure is very facile and selective for acetals derived from ketones and conjugated aldehydes. tert-Butyldimethylsilyl ethers are stable to the reaction conditions. The highly catalytic nature of bismuth triflate and the use of a relatively nontoxic solvent system (THF/H(2)O) make this procedure particularly attractive for large-scale synthesis.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(1,1-Dimethoxyethyl)benzene, 97%
Pricing and availability is not currently available.