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  • [Lessons from the novel renoprotective studies with antihypertensive drugs].

[Lessons from the novel renoprotective studies with antihypertensive drugs].

Orvosi hetilap (2013-02-12)
László Bajnok
ABSTRACT

From the evaluated ONTARGET, ALTITUDE, ACCOMPLISH, ROADMAP, and ACCORD-BP studies a conclusion can be drawn that though microalbuminuria/proteinuria is a strong epidemiological biomarker, in interventional studies it is not necessarily a reliable surrogate endpoint as actual renal function may change in an opposite way. Namely, some therapeutic measures improving microalbuminuria/proteinuria may actually worsen renal function. In case of procedures such as blood pressure lowering or measure of RAS blockade an optimum point on a J-curve may exist.

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Amlodipine besylate, ≥98% (HPLC)
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Supelco
Amlodipine besylate, Pharmaceutical Secondary Standard; Certified Reference Material
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Amlodipine for peak identification, European Pharmacopoeia (EP) Reference Standard
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Amlodipine besylate, European Pharmacopoeia (EP) Reference Standard
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