SnO(2)-ZnSn(OH)(6): a novel binary affinity probe for global phosphopeptide detection.

SnO(2)-ZnSn(OH)(6): a novel binary affinity probe for global phosphopeptide detection.

Chemical communications (Cambridge, England) (2013-01-25)

Li-Ping Li, Tao Zheng, Lin-Nan Xu, Ze Li, Ling-Dong Sun, Zong-Xiu Nie, Yu Bai, Hu-Wei Liu

ABSTRACT

ZnSn(OH)(6) and binary-component SnO(2)-ZnSn(OH)(6) were introduced as affinity probes for phosphopeptide enrichment for the first time. Two strategies, either ZnSn(OH)(6) and SnO(2) serial enrichment or binary-component SnO(2)-ZnSn(OH)(6) enrichment in a single run, were proposed to enhance multi-phosphopeptide enrichment and to significantly improve global phosphopeptide detection.

MATERIALS

Product Number

Brand

Product Description

244651

Sigma-Aldrich

Tin(IV) oxide, −325 mesh, 99.9% trace metals basis

549657

Sigma-Aldrich

Tin(IV) oxide, nanopowder, ≤100 nm avg. part. size

204714

Sigma-Aldrich

Tin(IV) oxide, ≥99.99% trace metals basis