Skip to Content
Merck

Human Immune System Variation during 1 Year.

Cell reports (2020-07-23)
Tadepally Lakshmikanth, Sayyed Auwn Muhammad, Axel Olin, Yang Chen, Jaromir Mikes, Linn Fagerberg, Anders Gummesson, Göran Bergström, Mathias Uhlen, Petter Brodin
ABSTRACT

The human immune system varies extensively between individuals, but variation within individuals over time has not been well characterized. Systems-level analyses allow for simultaneous quantification of many interacting immune system components and the inference of global regulatory principles. Here, we present a longitudinal, systems-level analysis in 99 healthy adults 50 to 65 years of age and sampled every third month for 1 year. We describe the structure of interindividual variation and characterize extreme phenotypes along a principal curve. From coordinated measurement fluctuations, we infer relationships between 115 immune cell populations and 750 plasma proteins constituting the blood immune system. While most individuals have stable immune systems, the degree of longitudinal variability is an individual feature. The most variable individuals, in the absence of overt infections, exhibited differences in markers of metabolic health suggestive of a possible link between metabolic and immunologic homeostatic regulation.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Sodium azide, BioUltra, ≥99.5% (T)
SKU
Pack Size
Availability
Price
Quantity