Skip to Content
Merck

Muscular effects of statins in the elderly female: a review.

Clinical interventions in aging (2013-01-29)
Shilpa Bhardwaj, Shalini Selvarajah, Eric B Schneider
ABSTRACT

Statins have demonstrated substantial benefits in supporting cardiovascular health. Older individuals are more likely to experience the well-known muscle-related side effects of statins compared with younger individuals. Elderly females may be especially vulnerable to statin-related muscle disorder. This review will collate and discuss statin-related muscular effects, examine their molecular and genetic basis, and how these apply specifically to elderly women. Developing strategies to reduce the incidence of statin-induced myopathy in older adult women could contribute to a significant reduction in the overall incidence of statin-induced muscle disorder in this vulnerable group of patients. Reducing statin-related muscle disorder would likely improve overall patient compliance, thereby leading to an increase in improved short- and long-term outcomes associated with appropriate use of statins.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Geranyl pyrophosphate ammonium salt, 1 mg/mL in methanol (:aqueous 10 mM NH4OH (7:3)), ≥95% (TLC)
Sigma-Aldrich
Geranyl pyrophosphate lithium salt, ≥95.0% (TLC)
Supelco
Geranyl pyrophosphate lithium salt, analytical standard
Sigma-Aldrich
Farnesyl pyrophosphate ammonium salt, methanol:ammonia solution, ≥95% (TLC)