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D3321

Sigma-Aldrich

Dipeptidyl Peptidase VII human

recombinant, expressed in Sf9 cells

Synonym(s):

DPP7, Quiescent cell proline dipeptidase

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About This Item

Enzyme Commission number:
3.4.14.-
UNSPSC Code:
12352204
NACRES:
NA.54

recombinant

expressed in Sf9 cells

Quality Level

200

form

solution

specific activity

≥1,500 units/μg protein
≥1500 units/μg protein

mol wt

89.1 kDa

relevant disease(s)

diabetes; cardiovascular diseases

shipped in

dry ice

storage temp.

−70°C

Application

Dipeptidyl Peptidase VII (DPP7), also known as DPP2 or quiescent cell proline dipeptidase, is a post-proline cleaving aminopeptidase that is expressed in quiescent lymphocytes . DPP7 is used to study the regulation of cell quiescence . Like DPP4, DPP7 may be useful in diabetes and vascular disease research .

Biochem/physiol Actions

DPP7 is essential for maintaining lymphocytes and fibroblasts in G(0). The inhibition of DPP7 results in apoptosis, which is mediated by the induction of c-Myc and p53 . DPP7 has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.

Physical properties

Contains amino acids 29 to end with a C-terminal His tag, MW=89.1 kDa

Unit Definition

One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg °C

Physical form

Supplied as a solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 220 mM imidazole, and 20% glycerol.

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Statements

H314,H360D

Hazard Classifications

Eye Dam. 1 - Repr. 1B - Skin Corr. 1C

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Certificates of Analysis (COA)

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Martin Kruse et al.
The Journal of general physiology, 140(2), 189-205 (2012-08-02)
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) regulates activities of numerous ion channels including inwardly rectifying potassium (K(ir)) channels, KCNQ, TRP, and voltage-gated calcium channels. Several studies suggest that voltage-gated potassium (K(V)) channels might be regulated by PI(4,5)P(2). Wide expression of K(V) channels in
Dipeptidyl peptidase 2 is an essential survival factor in the regulation of cell quiescence.
Mele DA, et al.
Cell Cycle, 15, 2425-2434 (2009)
Katrin Witzel et al.
Neuropharmacology, 63(8), 1389-1403 (2012-09-12)
We examined the effects of the sulfonylurea compound NS5806 on neuronal A-type channel function. Using whole-cell patch-clamp we studied the effects of NS5806 on the somatodendritic A-type current (I(SA)) in cultured hippocampal neurons and the currents mediated by Kv4.2 channels
Lin Zhu et al.
The Journal of general and applied microbiology, 58(3), 199-209 (2012-08-11)
Proteolytic degradation is one of the serious bottlenecks limiting the yields of heterologous protein production by Aspergillus oryzae. In this study, we selected a tripeptidyl peptidase gene AosedD (AO090166000084) as a candidate potentially degrading the heterologous protein, and performed localization
Mahesh Kamate et al.
Neurology India, 60(3), 316-320 (2012-07-25)
Neuronal ceroid lipofuscinosis is a group of progressive neurodegenerative disorders characterized by accumulation of ceroid lipopigment in lysosomes in neurons and other cell types. This study is a retrospective review of charts of patients with a diagnosis of infantile and
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