A0752

Adenosine 5′-diphosphoribose sodium salt

≥93%

• Synonym(s): ADPR, ADP-Ribose
• Empirical Formula (Hill Notation): C₁₅H₂₃N₅O₁₄P₂
• CAS Number: 68414-18-6
• Molecular Weight: 559.32
• MDL number: MFCD00136017
• UNSPSC Code: 41106305
• PubChem Substance ID: 24890449
• NACRES: NA.51

Properties

• biological source: yeast (candida utilis)
• Assay: ≥93%
• form: powder
• storage temp.: −20°C
• SMILES string: [Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C3O
• InChI: 1S/C15H23N5O14P2.Na.H/c16-13-9-14(18-4-17-13)20(5-19-9)15-12(26)11(25)8(33-15)3-32-36(29,30)34-35(27,28)31-2-7(23)10(24)6(22)1-21;;/h1,4-8,10-12,15,22-26H,2-3H2,(H,27,28)(H,29,30)(H2,16,17,18);;
• InChI key: NWPVXDZLQTURKI-UHFFFAOYSA-N

Description

Application

5′-Deoxy-5′-(methylthio)adenosine has been used:

• to give a range of nicotinamide adenine dinucleotide (NADH)
• oxidation rates for the respiratory complex (CI/CIII/CIV)
• CI/alternative(AOX) pathway
• to measure poly(ADP-ribose) glycohydrolaseactivity
• poly(ADP-ribose) (PAR) binding competition assay
• oxidase (AOX) pathway
• to measure poly(ADP-ribose) glycohydrolase activity
• poly(ADP-ribose) (PAR) binding competition assay

Biochem/physiol Actions

Adenosine5′-diphosphoribose (ADP-Ribose) is used as the basic building block used as a substrate in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family. Poly(ADP-ribose) formation and degradation are important components of DNA repair and apoptosis signaling. ADP-Ribose initiates the transient receptor potential subfamily melastatin, type2 (TRPM2), a Na⁺, Ca2⁺, and K⁺ cation channel.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves