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46945

Sigma-Aldrich

Fluorescein isothiocyanate–dextran

average mol wt 70,000, (FITC:Glucose = 1:250)

Synonym(s):

FITC-Dextran 70, FITC–Dextran

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About This Item

CAS Number:
60842-46-8
MDL number:
MFCD00131092
UNSPSC Code:
12352201
NACRES:
NA.32

biological source

synthetic

conjugate

FITC conjugate

form

powder

mol wt

average mol wt 70,000

composition

(FITC:Glucose = 1:250)

extent of labeling

~0.004 mol/mol FITC glucose

solubility

H2O: 50 mg/mL, hazy, orange to very deep orange

fluorescence

λex 492 nm; λem 518 nm in ethanol

application(s)

cell analysis

storage temp.

2-8°C

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Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
Fluorescein isothiocyanate–dextran (FITC-Dextran 70) is use as a fluorescent probe to study cell processes such as cell permeability, phagocytosis and endocytosis and to study mechanisms of biomolecular delivery. FITC-Dextran 70 may be used to study the capacity, selectivity and efficiency of encapsulation and release by drug delivery vehicles.

Other Notes

Internalisation of FITC and FITC-dextran by suspension cultured plant cells; In the study of fluid pinocytosis in leukocytes

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Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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L. Cole et al.
Journal of Cell Science, 96, 721-721 (1990)
Siegfried Weisenburger et al.
Cell, 177(4), 1050-1066 (2019-04-16)
Calcium imaging using two-photon scanning microscopy has become an essential tool in neuroscience. However, in its typical implementation, the tradeoffs between fields of view, acquisition speeds, and depth restrictions in scattering brain tissue pose severe limitations. Here, using an integrated
Use of horseradish peroxidase and fluorescent dextrans to study fluid pinocytosis in leukocytes.
J M Oliver et al.
Methods in enzymology, 108, 336-347 (1984-01-01)
Chuan He et al.
FEBS letters, 587(3), 285-290 (2012-12-25)
We have successfully delivered FITC and FITC-Dextran (70, 250 kDa) into canola protoplasts by centrifuging cells with different amounts of microbubbles at variable centrifuge speed. The efficiency is around 90%, while cell viability remains high. Confocal microscopy images show that
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