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209767

Sigma-Aldrich

2,2-Dichloro-1-methyl-cyclopropanecarboxylic acid

98%

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About This Item

Linear Formula:
Cl2C3H2(CH3)CO2H
CAS Number:
1447-14-9
Molecular Weight:
169.01
Beilstein:
1937304
EC Number:
215-901-6
MDL number:
MFCD00001291
UNSPSC Code:
12352100
PubChem Substance ID:
24852592
NACRES:
NA.22

Assay

98%

form

solid

bp

85 °C/8 mmHg (lit.)

mp

60-65 °C (lit.)

SMILES string

CC1(CC1(Cl)Cl)C(O)=O

InChI

1S/C5H6Cl2O2/c1-4(3(8)9)2-5(4,6)7/h2H2,1H3,(H,8,9)

InChI key

BIUUWIKPBYWKEQ-UHFFFAOYSA-N

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Application

2,2-Dichloro-1-methyl-cyclopropanecarboxylic acid was used in solid phase synthesis of α-hydroxy esters, inhibitors of amyloid-β production.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Owen B Wallace et al.
Bioorganic & medicinal chemistry letters, 13(6), 1203-1206 (2003-03-20)
Inhibitors of amyloid-beta (Abeta) protein production have been widely pursued as a potential treatment for Alzheimer's disease. Following the identification of a 5 microM screening hit, SAR was initiated using solid-phase synthetic techniques. Two series of alpha-hydroxy esters and ketones
Dmitriy Ovcharenko et al.
Cancer biology & therapy, 20(9), 1281-1289 (2019-06-27)
Dichloroacetate (DCA) is an inhibitor of pyruvate dehydrogenase kinase (PDK) that has been shown to reverse the Warburg effect and cause tumor cell death. Clinical research into the anti-cancer activity of DCA revealed high dosage requirements and reports of toxicity.

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